Hello from Norway.
So fare nobody mention the different between oxalic acid and the acaricides making resistence. It is very important to see the differences to understand the effect of oxalic acid. Oxalic acid is an acid which can not be directly compared with the acaricides. Varroa forms resistance against the acaricides just because they are designed in a way making varroa able to make changes over time and survive. Oxalic acid is very acidifying in the solution used for dripping. If oxalic acid didn`t give an acidfying effect, it would not give any effect. To make resistence against something that etches on the surface outside of the body or inside, is more or less impossible for the varroa to form resistance to. We see the same by the way the food industries are cleaned. As long as you are using cleaning agents and routines alternating between agents based on caustic soda and acids which attach the surfaces, resistance is not formed because it is the substances' ability to corrode/etch the bacteria's surface that kills the organisms. The Japanese have used oxalic acid for varroa treatment since the 1960s without any evidence of resistance, and as long as oxalic acid has an acid effect, the effect will be very demanding for the varroa to cope with.
On the other hand, we have seen a deterioration that worries us. One treatment in the fall as only treatment/action against varroa is not enough to prevent break down any longer. I myself have been using oxalic 20 years. The first 15 years the only treatment was a drippeling in November, nothing else to be done. But I can see a build up of varroa in July/August which kills hives during winter. Now I make tests with two treatments, one in start of October and one in the start of December. By drone frame inspections in summer after two treatments, the number of varroa is very limited and makes no harm so fare. When the detected varroa is so low, I consider whether two treatments every two years would perhaps have worked. Mixing ratio of solution: Oxalic acid dihydrate 150g, water 2 liter and sugar 2kg. Used between the frames: 3,5ml hitting the bees.
Why is one treatment not enough anymore? Do the number of varroa increase due to reduced effect? No, the number of varroa falling down by one treatment is more or less stable, but it is likely to believe the virus spread between the bees are more dangerous. Of that reason it is important to get rid of as many varroa as possible early in the autumn in order to reduce the number of mites that spread dangerous viruses before it is too late. The climate changes is also starting to be challenging. The bees are breeding to November which we rarely experienced before, and with the breeding, more varroa. I am very interested in getting the experiences of others who fight varroa in a similar way as described here.