Ely,
Your questions seem (to me) to imply that you are asking about a single treatment approach, whereas the general view is that we need to adopt forms of multiple approach, through Integrated Pest Management (IPM).
So back to basics: the approach one takes should be based on an assessment of the problem - which for varroa is primarily about assessing numbers of varroa in the colony as the bees move through each stage of their lifecycle. Moreover, the treatment should be part of an IPM approach that is matched to the numbers of varroa, but which will always have more than one component across a season, by which I mean more than one of: oxalic acid treatment, shook swarm, drone brood culling, artificial swarm, thymol, and possibly more. Each is particularly effective when administered at its right time within the bees' annual lifecycle (and can be largely ineffective or damaging to the bees outside of that time).
The exact treatment will vary year to year, based on that assessment of the varroa numbers. If you have not done so then go to the Fera site and read (and follow as appropriate) its excellent guide "Managing Varroa".. It is here, under Fera's Advisory Leaflets, Training Manuals & Fact Sheets page: https : // secure.fera.defra.gov.uk/beebase/index.cfm?pageid=167.
(sorry for the cut-up link, but I am not allowed to post links untill having completed 10 posts.)