We're in a similar position, part of the house dates back to 16th century, "newer" bit is elizabethan, apart from a new extension by us 20 years ago.
Thick stone walls, listed so external insulation definitely out (& we wouldn't). We only installed double glazing a year ago, after having to apply for permission & having to use an expensive, though sympathetic, option.
Internal insulation remains an option as and when we redecorate each room.
A hybrid system might be an option (googled it) but might not be very beneficial!