Question regarding effects of multi mating.

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most resistant?

Resistant is enough.

In many advices it is said that change the queen.

I have had that disease 40 years ago, and it went away every time with changing queen.

One thing is too that if I see a porous brood area, the queen will go to buches.
 
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Difficult to say about sub species. In practice bees are more or less hybrids and races have much variation.
 

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