I reckon you could do a double layer of 25mm PIR for the side walls which would enable you to create a landing for the frame lugs, UPVC strip for the frame lugs to sit on, the end walls single 25mm PIR and all ply lined Hand holds in the double skinned side walls would be formed from small plastic boxes recessed into the outer skin. Top bee space, the top edge of the box protected again with UPVC strip and a clear crownboard without the need for a rim. Bottom edge again protected with UPVC .. timber floor of course. Deep PIR roof with 50mm top.