Not particularly up to speed on rifles these days. Are these rim or centre fire?
Treble 2, 2250 and 270 were always the considerable steps up in power and accuracy over the 0.22 rim fire. Not come across either of those two calibres mentioned.
For the same muzzle power, the lighter projectile will have a flatter trajectory over the shorter ranges, simply because of the higher velocity with the same drop, due to gravity, over the same time period. Windage factors would benefit the heavier load. So a lot would depend on type of target and range, I would think.
I used to find that sub-sonic shorts gave better accuracy (over the more limited range) than long rifle high power 0.22 rim fire, but that was a long time ago with a Browning T-bolt.
RAB