Portuguese reversivel hives (used widely in the south) are run - as I understand it - on a Warre-like system, but in boxes (not dissimilar to nationals in size) with moveable frames. That is to say they generally use a single size of box, no excluder, and under-super.
... So it's clearly viable as a commercial 'method'.
Like
@pargyle , I am experimenting - both with a standard Warre, and with foundationless nationals, run on similar principles (and with solid floor, XYZ intrances etc...).
Whilst I've only been running the latter for a couple of years, my initial thoughts are that the bees seem more settled. Swarming is minimal, and Queens are not getting replaced as frequently. Maybe just coincidence.
On the honey quality (from the Warre), whilst I think you'd be hard-pushed to assert it contained beneficial compounds equivalent to Manuka, the fact that the comb has previously been used for brood, and the fact that, when crushed, pollen in any cells bleeds out into the honey in great quantity both mean that the resulting honey I have extracted is super, super rich and aromatic. I've had it described to me as 'honey to the power of ten' and 'honey on steroids'.
Of course, those who choose not to believe me are welcome to opine that it's all bollocks