Winter bees are already mostly out of their cells by now, and if you haven't treated yet then they probably shared those cells with varroa mites, and thus may have viruses of some sort - vaping in late October is too late to help them with that.
You need to be culling the mite population in August and September, so that there are fewer mites around to infect the winter bees as they develop in September and October.
But if you haven't done it at all, then yes, do it now, using the timetable JBM set out. Just do it earlier in future years, IMHO.