Finman
Queen Bee
- Joined
- Nov 8, 2008
- Messages
- 27,887
- Reaction score
- 2,024
- Location
- Finland, Helsinki
- Hive Type
- Langstroth
.
Here is text from year 2010 USA entomology edu
http://entomology.unl.edu/faculty/ellispubs/Pesticides.pdf
Two organic acids, formic acid and oxalic
acid, are attractive options as varroacides
because both are naturally present in honey
(Bogdanov, 2006; Rademacher and Harz,
2006). Formic acid is registered with Section 3
approval in the USA under the trade name
MiteAway II! (NOD, 2009).
MiteAway II!is a fumigant varroacide that is packaged in a
slow release pad. Formic acid likely kills Varroa
by inhibiting electron transport in the mitochondria
through binding of cytochrome c
Honey bee toxicity – USA 7
oxidase, thereby inhibiting energy metabolism
(Keyhani and Keyhani, 1980) and may produce
a neuroexcitatory effect on arthropod
neurons (Song and Scharf, 2008). Formic acid
can harm honey bees by reducing worker
longevity (Underwood and Currie, 2003) and
harming brood survival (Fries, 1991).
Oxalic acid is registered for use as a varroacide
in Canada and Europe, but not in the
USA.
In Canada it is trickled over honey bees
in a sugar syrup solution (Canadian Honey
Council, 2005) or sublimated using a vaporizer
(Varrox, 2007). Research has shown it
to be highly effective against Varroa in cool
climates when brood is not present (Aliano
and Ellis, 2008). The mode of action of oxalic
acid against Varroa is unknown, but direct
contact between Varroa and oxalic acid
is required (Aliano and Ellis, 2008). Oxalic
acid treatments administered in water are ineffective
(Charrière and Imdorf, 2002), but administration
in sugar water improves efficacy
by adhering the active ingredient to the bees
(Aliano and Ellis, 2008). In mammals, oxalic
acid interfereswith mitochondrial electron
transport, probably through interaction with
complex II or IV, leading to increased production
of reactive oxygen species and to kidney
toxicity (Cao et al., 2004; Meimaridou et al.,
2005). Repeated treatment of colonies with
oxalic acid can result in higher queenmortality
and a reduction in the amount of sealed brood
(Higes et al., 1999). The midguts of honey
bees fed oxalic acid in sugar water exhibited
an elevated level of cell death (Gregorc and
Smodisskerl, 2007), though in field conditions
bees will generally avoid consuming syrup
with oxalic acid (Aliano and Ellis, 2008).
Oxalic acid is readily available and inexpensive
in the USA for use as a wood bleach but it is not labeled for use in controlling Varroa.
Its easy availability from many sources
has limited the willingness of suppliers to undergo
the expensive and time-consuming registration
process.
Here is text from year 2010 USA entomology edu
http://entomology.unl.edu/faculty/ellispubs/Pesticides.pdf
Two organic acids, formic acid and oxalic
acid, are attractive options as varroacides
because both are naturally present in honey
(Bogdanov, 2006; Rademacher and Harz,
2006). Formic acid is registered with Section 3
approval in the USA under the trade name
MiteAway II! (NOD, 2009).
MiteAway II!is a fumigant varroacide that is packaged in a
slow release pad. Formic acid likely kills Varroa
by inhibiting electron transport in the mitochondria
through binding of cytochrome c
Honey bee toxicity – USA 7
oxidase, thereby inhibiting energy metabolism
(Keyhani and Keyhani, 1980) and may produce
a neuroexcitatory effect on arthropod
neurons (Song and Scharf, 2008). Formic acid
can harm honey bees by reducing worker
longevity (Underwood and Currie, 2003) and
harming brood survival (Fries, 1991).
Oxalic acid is registered for use as a varroacide
in Canada and Europe, but not in the
USA.
In Canada it is trickled over honey bees
in a sugar syrup solution (Canadian Honey
Council, 2005) or sublimated using a vaporizer
(Varrox, 2007). Research has shown it
to be highly effective against Varroa in cool
climates when brood is not present (Aliano
and Ellis, 2008). The mode of action of oxalic
acid against Varroa is unknown, but direct
contact between Varroa and oxalic acid
is required (Aliano and Ellis, 2008). Oxalic
acid treatments administered in water are ineffective
(Charrière and Imdorf, 2002), but administration
in sugar water improves efficacy
by adhering the active ingredient to the bees
(Aliano and Ellis, 2008). In mammals, oxalic
acid interfereswith mitochondrial electron
transport, probably through interaction with
complex II or IV, leading to increased production
of reactive oxygen species and to kidney
toxicity (Cao et al., 2004; Meimaridou et al.,
2005). Repeated treatment of colonies with
oxalic acid can result in higher queenmortality
and a reduction in the amount of sealed brood
(Higes et al., 1999). The midguts of honey
bees fed oxalic acid in sugar water exhibited
an elevated level of cell death (Gregorc and
Smodisskerl, 2007), though in field conditions
bees will generally avoid consuming syrup
with oxalic acid (Aliano and Ellis, 2008).
Oxalic acid is readily available and inexpensive
in the USA for use as a wood bleach but it is not labeled for use in controlling Varroa.
Its easy availability from many sources
has limited the willingness of suppliers to undergo
the expensive and time-consuming registration
process.