strap them down..
Only real difference are the obvious ones..
1). You cannot torch boxes out. So need to use some chemical alternative to sterilise them.
2). They weigh a lot less. So when the bees are light on stores etc or winds are high, you will almost certainly need to strap them down.
3). Watch your smoker fuel. If you use something like saw dust etc, where you get the odd ember ejected, when trying to uselots of smoke, you may singe your boxes. Takes a fair bit to get them burning properly, so don't worry about that. But the odd hot ember will melt a hole.
Otherwise, even though I don't use them, i will acknowledge they due seem to encourage an earlier build up in brood.